The Nathaniel Massie Chapter of the Daughters of the American Revolution was organized January 3, 1895, in Chillicothe, Ohio. Regent Miss Mary Petrea McClintock led the founding efforts, and charter members named the chapter after Revolutionary War soldier Nathaniel Massie, who had laid out the town of Chillicothe one hundred years earlier. In 1896, the NSDAR granted charter #167 to the Nathaniel Massie Chapter.

Charter members were Miss Mary Petrea McClintock, Mrs. William McClintock, Mrs. Albert Douglas, Miss Ann Sill Douglas, Miss Jane Marfield, Mrs. David Meade Massie, Miss Maria McKell, Miss Caroline Sproat, Mrs. Louis D. Sproat, Miss Emma Sproat, Miss Eliza VanMeter, and Miss Susan Walke. By 1903, the chapter had grown to 23 members; by 1928, that number had increased to 58.

In 1969, the Waverly Chapter NSDAR petitioned the national board to disband and join the Nathaniel Massie Chapter. Upon approval, the addition of the Waverly members to the Nathaniel Massie Chapter raised membership to 105.

Today, the chapter participates in a wide range of activities including service to veterans and current military personnel, the promotion of patriotism, literacy advocacy, genealogical research, historical preservation, and support and assistance to national, state, and local projects.